The data available in MethyCancer are highly integrated and consist of information on cancer-related information from various public resources, genes and genetic mutations known to be involved in cancer, human DNA methylation patterns, and CpG Island (CGI) clones created from the Cancer Epigenomic Project in China's massive-scale high-throughput sequencing of the human epigenome. Data on DNA methylation patterns and profiles available from MethyCancer are primarily sourced from Methylation Landscape of the Human Genome(Columbia University), the Human Epigenome Project (HEP), and MethDB  . The MethyCancer analysis platform is useful for research involving the identification of new cancer-related genes and epigenetic targets, the genome-wide distribution of CGIs, the relationship between known oncogenes and the methylation state of DNA, and complete DNA methylation patterns and profiles for a variety of tissues and phenotypes derived from thousands of independent experiments.
Peer-Reviewed Journal Articles Citing MethyCancerEdit
1. Li M & Chen S (2011) The tendency to recreate ancestral CG dinucleotides in the human genome . BMC Evol. Bio. 11:3.
2. Talikka M, et al. (2012) Genomic impact of cigarette smoke, with application to three smoking-related diseases. Critic. Revs. in Toxic. 42(10):877-889.
3. Su J, et al. (2013) CpG_MPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data. Nucl. Acids Res. 41(1):e4.
1. Berdasco M & Esteller M (2010) Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry. Developmental Cell. 19(5):698-711.
2. He X, et al. (2008) MethyCancer: the database of human DNA methylation and cancer. Nucl. Acids Res. 36(suppl1):D836-D841.