Genome Wide Association Studies (GWAS) focus on identifying specific genetic factors that increase an individual's susceptibility to disease.  Single-nucleotide polymorphisms (SNPs), whereby there is a sole nucl

GWA Catalog of 17 trait categories

eotide change amongst individuals of a particular species, has been a powerful tool for these studies.  SNPs serve as markers for links to normal or disease outcomes.  Publications of GWA studies are catalogued through the National Insitutes of Health to provide a central hub of information to the public.  These studies aim to provide a relationship between differences in individual sequences and increased susceptibility for particular diseases.  Furthermore, to gain an understanding of allelic makeup involved in complex traits.  Particular diseases, such as breast cancer and diabetes, have had a rapid expansion of knowledge from GWA studies due to a large number of loci implicated in predisposition (McCarthy et al., 2008).  Other diseases, such as asthma and coronary heart disease, have had fewer loci found to be associated with predisposition to disease. 


Hirschhorn JN and Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet. 2005 (2): 95-108.

McCarthy MI., Abecasis GR., Cardon LR., Goldstein DB., Little J., Loannidis JP., and Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature. 2008 (9) 356-369.

Single-nucleotide polymorphism Wiki

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