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Gene Database: MissionEdit

Gene is one of the databases under the National Center for Biotechnology Information (NCBI). Its purpose is to provide information about a particular gene such as variations, location (s) on a chromosome and ongoing studies. This database is useful for genomes that have been completely sequen ced, especially if one does not know any other information of the gene or protein of interest.

HistoryEdit

Not much is known about how Gene became part of NCBI. NCBI was founded in 1988 in order to provide databases for others to use. Sometime after 1992, Gene was added as one of the databases in addition to others such as the Molecular Modelling Database.

How to Use GeneEdit

  1. To access Gene, Google NCBI. On the left hand side, is Genes and Expressions tab. When that is clicked, Gene is one of the databases available.
    Search

    Search engine results. Multiple organisms can be found for this one protein of interest. http://www.ncbi.nlm.nih.gov/gene/?term=COMT

    Summary COMT

    Summary of COMT gene. This provides the taxonomy of organism of interest, gene type, function of the gene, and the original primary source. http://www.ncbi.nlm.nih.gov/gene/1312

  2. Type in any gene or protein of interest. Example used would be Catechol-O methyltransferase (COMT) gene. The abbreviation or full name of protein or gene of interest are acceptable.
  3. Search engine would give different results of the COMT Gene for different organisms. In this example, click on Homo Sapien.
  4. Below are some major sections of the site:
  • The first section is the summary. It would give information such as any abbreviations and the function of a gene.  
  • The second section is Genomic Context. It provides the location and sequence of the gene on the chromosome.
  • The third section is Genomic region, products, and transcripts, where it gives a picture of where the gene is and nearby genes.
  • Bibliography gives search results associated with the gene. It provides any current literature about the protein or gene of interest.
  • Phenotyp
    Genomic Context

    Snapshot of Genomic Context. This provides location of sequence of the genome. http://www.ncbi.nlm.nih.gov/gene/1312

    es provides any known phenotypes associated wit
    Genes and transcripts

    Under Genomic regions, transcripts, and products, nearby genes and variants of protein of interest can be found.

    h this gene.

Links:Edit

http://www.ncbi.nlm.nih.gov/gene/1312

http://en.wikipedia.org/wiki/National_Center_for_Biotechnology_Information

http://www.ncbi.nlm.nih.gov/books/NBK21105/#ch1.History