Dynamed is not so traditional as a database. It's more clinical. I strongly recommend this database because you may get a huge mount of information of genes from genebank, pubmed and other bioinformatics databases. These data are abstract and theoretical, and to some extent, not understandable. For example, BRCA1, the breast cancer gene which is intensively and extensively researched for many years. However, you may have no specific idea even after extensively reading of scientific papers of Science, Nature, Cells and other bioinformatic journal. It's better for you to go DynaMed website. You can access via UVM dana library , find Articles and Databases category, and then choose DynaMed if your computer in campuse IP. You may also access outside of college, but you would be required to type in your UVM NetID and password.
When you login in Dynamed, just simply type in the name of gene, say ,BRCA1. you will see a list of relevant topics, such as Recommendations for Screening, Prevalence, Risk for Cancer, Genetic Counseling of High-risk Family, Screening, Risk Reduction Measures, Guidelines and Resources, Patient Information.
Find Information for a specific diseaseEdit
If you have an interest in a specific disease, for example, primary biliary cirrhosis (PBC), after you type in name of disease, a variety of topics of this disease can be found in this category: general information, causes and risk factors, complications and associated conditions, history and physical, diagnosis, prevention and screening, guidelines and resources, patient information. If you want to find genetics-relevant content , usually go to " causes and risk factors". For Primary biliary cirrhosis (PBC), based on genomewide association analysis of DNA from 2,072 persons (536 with primary biliary cirrhosis and 1536 controls). Primary biliary cirrhosis associated with
13 loci across HLA class II region
2 single-nucleotide polymorphisms at IL12 A locus, rs 6441286 and rs574808
1 single-nucleotide polymorphism at IL12RB2 locus
5-allele haplotype in 3' flank of IL12A significantly associated with primary biliary cirrhosis
modest genomewide association with risk of disease for single-nucleotide polymorphisms at STAT4 and CTLA4 locus and 10 other loci.
Find clinic full-text papersEdit
The most amazing thing is you can see the clinic paper in full text from NEJM, Lancet, JAMA, Am Fam Physician. These papers are totally different from the papers from Science, Nature, etc. Via reading these papers , I am pretty sure you will have deep understanding what's the gene exactly is, how the gene relevant to human health, how the doctors and scientists deal with the problems concerning the gene.