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Database of Genomic Variants, as known as DGV, is  a database dedicated to provide a full-scale summary  of genomic alternations (especially those involving DNA segements that are longer than 50bp) in human genome.

http://dgv.tcag.ca/dgv/app/home

HistoryEdit

Established in 2004, DGV accepted direct submission of CNV data into the database. In 2009, the current version of DGV was launched and became part of collaboration with DGVa and dbVAR (two archival CNV databases at EBI and NCBI). The database was first described in Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet. 2004 Sep;36(9):949-51.

UtilityEdit

The New Database of Genomic Variants -- DGV2 (edited)

The New Database of Genomic Variants -- DGV2 (edited)

Users could search by keyword, landmark or region of a certain piece of DNA and receive comprehensive information regarding different structural variations of the gene of their interests. This is particularlly helpful for those who intend to correlate genomic variations with phenotypes. Users who are interested in a particular piece of gene could use this database to find out almost all possible variants or alternations that could take place on the gene.

Example of UseEdit

CFTR

Fig 1: Browsing DGV. Enter keyword, landmark or region into the blank to start browsing.

Taking CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) as an example.

1. Type CFTR (or whatever gene of interest or keyword, etc) into the search bar on the homepage and hit Enter (Fig. 1).

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Fig 2: Search result

2. Then you will be directed to the page shown in Fig. 2. The Overview part shows the location of CFTR gene between the two red lines and you can zoom in on any part of the gene to see more details. The Landmark or Region bar provides the exact location of CFTR gene (Chr7 

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Fig 3: nsv889076(Xu2011)variation

116,907,253..117,095,954). In Details section, you can click on any bars or lines for more detailed information. For instance, in the DGV Structural Variants subsection, different possible variantions of the CFTR gene are represented in colored bars, clicking on red bar under nsv889076(Xu2011) will take you to the page that shows more information about this variation (Fig. 3). 


The database itself provides a more comprehensive guide of use, if you are interested, here's the link : http://dgv.tcag.ca/dgv/docs/DGV_Webinar_December_8_2011.pdf

ReferenceEdit

1. http://dgv.tcag.ca/dgv/app/home

2. Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet. 2004 Sep;36(9):949-51

3. http://dgv.tcag.ca/dgv/docs/DGV_Webinar_December_8_2011.pdf